Human psap protein

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August undefined, 2024

WebPSAP is a highly conserved glycoprotein which is a precursor for 4 cleavage products: saposins A, B, C, and D. Each domain of the precursor protein is approximately 80 … Web21 Dec 2024 · Prosaposin (PSAP) is also a multifunctional neuroprotective secreted protein and regulator of lysosomal function. Interactions of PGRN and PSAP affect their …

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Web2 Feb 2024 · Specifically, PPS proteins are enriched in G, arginine (R), proline (P), serine (S), asparagine (N), and aspartate (D). Conversely, PPS proteins show depletion for leucine (L), valine (V), threonine (T), isoleucine (I), histidine (H), cysteine (C) and tryptophan (W) (Figure 1B). Web14 Sep 2015 · PGRN is a resident lysosomal protein and trafficked to the lysosome via two independent pathways, directly by the sortilin receptor (13) or indirectly by binding to the soluble lysosomal... black progress matters careers

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WebSaposins are specific low-molecular mass non-enzymic proteins, they participate in the lysosomal degradation of sphingolipids, which takes place by the sequential action of … Web15 Mar 2024 · Vial Types Available for Donor #95022. All prices shown are in USD. $1350 per vial Identity Disclosure xyGene Washed. $1350 per vial Identity Disclosure xyGene Unwashed. $825 per vial Identity Disclosure xyGene ART. Due to inventory, above prices do not guarantee that listed vial types are currently available. WebPrimary Antibodies All Primary Antibodies 16193565 prosaposin, Rabbit, Purified MaxPab™ Polyclonal Antibody, Abnova™ Rabbit polyclonal antibody raised against a full-length human PSAP protein. Brand: Abnova H00005660-D01P.100ug Additional Details : Weight : 0.00010kg Product Code. 16193565 £278.00 / 100µg Estimated Shipment: 02-05-2024 garmin 910xt watch

Prosaposin mediates inflammation in atherosclerosis Science ...

WebMouse monoclonal [6F10] to Surfactant Protein A/PSAP. Application: IHC-P, WB. Reactivity: Human. Conjugate: Unconjugated. Anti-Serum Amyloid P/SAP antibody … WebProsaposin is the precursor of four smaller proteins called saposin A, B, C, and D, which are produced when prosaposin is broken up (cleaved). The individual saposins are found in cellular structures called lysosomes, which are the cell's recycling centers. The saposins help lysosomal enzymes break down fatty substances called sphingolipids. black profile shutterWeb23 Sep 2024 · September 23, 2024. Genetics Neuroscience. Using new technologies to explore the entire genome of a human neuron, a research team has identified the PSAP gene as important for the cell’s survival and discovered the complex biological mechanism explaining the gene’s function. The findings appeared recently in Nature Neuroscience. black progressive shows

"Web10 Mar 2024 · Psap surfaced as a key-regulating gene. This gene encodes prosaposin, a highly conserved lysosomal protein involved in glycosphingolipid metabolism. As its role in atherosclerosis is unknown, we set out to study how prosaposin mediates inflammation in monocytes and macrophages. " - Human psap protein

Human psap protein

CD162/PSGL-1 Protein, Human (HEK293, His-Fc)

Web13 Mar 2024 · Recombinant Human PSAP protein (ab283432) Datasheet Submit a review Submit a question $495 Product size 100 µg $495 50 µg $335 10 µg $185 Add to basket … Web18 Apr 2024 · In these assays, Protein A shed from the beads, then bound to (and was eluted from) an immunoaffinity matrix designed to capture AD-related proteins. The …

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Web21 Mar 2024 · Molecular function for PSAP Gene according to UniProtKB/Swiss-Prot Saposin-A and saposin-C stimulate the hydrolysis of glucosylceramide by beta …

WebDescription: Mus musculus prosaposin (Psap), transcript variant 2, mRNA. (from RefSeq NM_011179) RefSeq Summary (NM_001146120): This gene encodes a multifunctional glycoprotein that plays a role in the intracellular metabolism of various sphingolipids or secreted into the plasma, milk or cerebrospinal fluid. The encoded protein undergoes … WebProsaposin (sphingolipid activator protein 1) antibody; prosaposin (variant Gaucher disease and variant metachromatic leukodystrophy) antibody; Prosaposin antibody; Protein A …

WebTransmembrane Protein; Recombinant Human Prostatic acid phosphatase(ACP3)-VLPs; Recombinant Human Prostatic acid phosphatase(ACP3)-VLPs. Code: CSB-MP001181HU(F2) Size: $6678: Image: CSB-MP001181HU(F2) is detected by Mouse anti-6*His monoclonal antibody. WebClinVar archives and aggregates information about relationships among variation and human health. An official website of the United States government. Here's how you know. ... (PSAP):c.911A>G (p.Lys304Arg) AND Sphingolipid activator protein 1 deficiency. Clinical significance: Uncertain significance (Last evaluated: ...

WebTo give an overview of the comparison of these DEPs associated with the neuro-impairment, five categories: (1) neuropathologies in human brain, (2) neuropathologies in mice/monkeys, (3) plasma protein changes after COVID-19, (4) CSF protein changes in COVID-19 patients, and (5) plasma proteins association with COVID-19 severity have been used.

WebTwo nonstructural proteins, NS3 and NS3A, have been implicated in this process. Here we show that both proteins bind to human Tsg101 and its ortholog from Drosophila melanogaster with similar strengths in vitro. This interaction is mediated by a conserved PSAP motif in NS3 and appears to play a role in virus release. garmin 920 heart rate monitorWeb1 Sep 2015 · We found that prosaposin (PSAP) interacts with PGRN and facilitates its lysosomal targeting in both biosynthetic and endocytic pathways via the cation-independent mannose 6-phosphate receptor and low density lipoprotein receptor-related protein 1. black professional tennis playersWebOn a yeast 2-hybrid screen of a human brain cDNA library for proteins that interact with the C terminus of presenilin-1 (PSEN1; 104311), Xu et al. (1999) identified a novel cDNA, which they designated PSAP (presenilin-associated protein). The deduced 371-amino acid PSAP protein has a predicted molecular mass of 39.9 kD and contains a PDZ-like domain and … black progressive womenWeb5 Apr 2024 · Interestingly, this peptide exhibits a PSAP motif , which is also found as P(S/T)AP in the C-terminal p6 domain of the HIV-1 Gag protein. It has been shown that the P(S/T)AP motif is a Gag late domain that recruits the cellular protein Tsg101 to exploit the cellular ESCRT machinery (Endosomal Sorting Complexes Required for Transport) for … black pro headlightsWebby Protein › PSAP Antibodies PSAP Antibodies Antibodies that detect PSAP can be used in several scientific applications, including Immunohistochemistry, Western Blot, Immunocytochemistry, ELISA and Flow Cytometry. These antibodies target PSAP in Human, Mouse and Rat samples. garmin 920xt bluetooth modeWebMain locationi. Main subcellular location (s) and reliability score (s) for the encoded protein (s) in human cells. The main location (s) may be characterized by presence in all tested cell lines and/or higher staining intensity compared to the potential additional location (s). Vesicles (supported) 1 HPA004426: A-431. garmin 920xt editing swimsWeb30 Dec 2024 · Pulmonary hypertension is a debilitating and progressive disease that includes 5 main subgroups. The only potentially curable subgroup is chronic thromboembolic pulmonary hypertension (CTEPH). 1 CTEPH is a form of precapillary pulmonary hypertension that occurs with the persistence of pulmonary thromboemboli, eventually … garmin 920xt changing watch strap